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Ehsan Rezaei

I am interested in discovering and designing new targeted drugs to treat cancer. My Ph.D. thesis was about immunotoxin and its effects on cancer treatment, entitled “Design and production of scfv-PE38 immunotoxin against EPHA2 receptor and evaluation of its effects on breast cancer cells” under the supervision of Dr. Jafar Amani. After that, We developed several immunotoxins against liver and lung cancer.

Living in : Iran

Gender : MaleRace : East Asian

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Academic Profile

Posts

Contact Information

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EhsanRezaeiApplyChance Link

Educations

Molecular Cell BiologyPhDRazi University Kermanshah2019-11-23 Iran

Cell And Molecular BiologyMaster'sUniversity of Imam Hossein2014-03-01 Iran

MicrobiologyBachelor'sIslamic Azad University, Karaj2011-02-28 Iran

Work Experiences

Senior researcher

at Baqiyatallah unversity of

I am currently working in this role

Conferences

Your Presentation Title :

Adjuvant use of melatonin as a potent anti-inflammatory to improve clinical outcomes in COVID-19 patients

Conference Name :Virtual International Congress

Iran

2021

Your Presentation Title :

Expression, extraction, purification and immunization of Binding Domain of Tetanus Neurotoxin and isolation of polyclonal antibody against it

Conference Name :8th national Biotechnology

Iran

2013

Your Presentation Title :

Comparison between memory B cell populations induced by botulinum toxin binding domain and tetanus toxin binding domain in mice model

Conference Name :International Congress Immunol

Iran

2012

Journal Publications

Publication Title :

A novel shiga based immunotoxin against Fn-14 receptor on colorectal and lung cancerFirst author

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International Immunopharmacology

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Publication Title :

Prediction of Genes Involved in Lung Cancer with a Systems Biology Approach Based on Comprehensive Gene InformationFirst author

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Biochemical Genetics

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Publication Title :

The tissue expression of MCT3, MCT8, and 11 MCT9 genes in women with breast cancerFirst author

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Genes and Genomics

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Publication Title :

A new scfv-based recombinant immunotoxin against EPHA2- overexpressing breast cancer cells; High in vitro anti-cancer potencyFirst author

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European Journal of Pharmacology

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Publication Title :

A highly potential cleavable linker for 16 tumor targeting antibody-chemokinesFirst author

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Journal of Biomolecular Structure and Dynamics

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Publication Title :

Bioinformatics Predictions, Expression, Purifcation and Structural Analysis of the PE38KDEL-scfv Immunotoxin Against EPHA2 ReceptorFirst author

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International Journal of Peptide Research and Therapeutics

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Application of molecular dynamics simulations to design a dual-purpose oligopeptide linker sequence for fusion proteinsFirst author

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Journal of Molecular Modeling

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Application of DNA shuffling as a tool for hydrolase activity improvement of pseudomonas strainSecond author

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Biointerface Research in Applied Chemistry

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Publication Title :

Different frequencies of memory B-cells induced by tetanus, botulinum, and heat- labile toxin binding domainsFirst author

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Microbial Pathogenesis

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Knockdown of SIX4 inhibits pancreatic cancer cells via apoptosis inductionSecond author

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Medical Oncology

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Publication Title :

The Trend of IgG and IgM Antibodies During 6-Month Period After the Disease Episode in COVID-19 PatientsFourth author

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Iranian Journal of Science and Technology - Transactions of Mechanical Engineering

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Publication Title :

Efficacy of a Low Dose of Melatonin as an Adjunctive Therapy in Hospitalized Patients with COVID-19: A Randomized, Doubleblind Clinical Trial: Adjuvant treatment of melatonin in COVID-19 patientsCorresponding author

Journal :

Archives of Medical Research

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Publication Title :

Bioinformatic prediction and experimental validation of a PE38-based recombinant immunotoxin targeting the Fn14 receptor in cancer cellsFourth author

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Immunotherapy

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Publication Title :

Engineering of cytolethal distending toxin b by its reducing immunogenicity and maintaining stability as a new drug candidate for tumor therapy; an in silico studyCorresponding author

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Toxins

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Publication Title :

miR‐9: From function to therapeutic 18 potential in cancerCorresponding author

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Journal of Cellular Physiology

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Publication Title :

An Integrated Data Analysis of mRNA, miRNA and Signaling Pathways in Pancreatic CancerCorresponding author

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Biochemical Genetics

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Publication Title :

Immunotoxins Immunotherapy against Hepatocellular Carcinoma: A Promising ProspectCorresponding author

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Toxins

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Publication Title :

Inhibitory effect of coumarin and its analogs on insulin fibrillation/cytotoxicity is depend on oligomerization states of the proteinCorresponding author

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RSC Advances

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Publication Title :

DT389-YP7, a Recombinant Immunotoxin against Glypican-3 That Inhibits Hepatocellular Cancer Cells: An In Vitro StudyCorresponding author

Journal :

Toxins

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Publication Title :

Engineering of Cytolethal Distending Toxin B by Its Reducing Immunogenicity and Maintaining Stability as a New Drug Candidate for Tumor Therapy; an In Silico StudyCorresponding author

Journal :

Toxins

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Publication Title :

Predicting COVID-19 models for death with three different decision algorithms: analysis of 600 hospitalized patientsCorresponding author

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Journal of Applied Biotechnology Reports

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Publication Title :

Design of two immunotoxins based rovalpituzumab antibody against DLL3 receptor; a promising potential opportunityFourth author

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Research in Pharmaceutical Sciences

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Publication Title :

A new combination: Anti glypican-3 scFv and diphtheria toxin with the best flexible linkerCorresponding author

Journal :

Protein Journal

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Research Keywords

bioinformatics

drug design

Immunotherapy

Cellular biology and immunology

Inflammation studies

Cell-based therapy

Awards

TOP-TALENTin the doctoral2014-09-22

Excellent studemaster's level2011-09-22

References

Mohammad Heiat

mohamad.heiat@gmail.com

Mahmood Bozorgmehr

mahmood_b58@yahoo.com