I study pain across two fronts: short-term postsurgical pain and long-term chronic pain. In the lab, I test safer treatments for nerve injury and chemotherapy-related nerve pain, and I study inflammation-driven arthritis pain. In clinics, I work with people who have substance-use disorders and overlapping pain, using careful, stepwise care and safer medicines when needed. I also look at how poor sleep and anxiety worsen pain and how evidence-based sleep therapy can help. My approach follows modern pain science, which groups pain as nociceptive, neuropathic, and nociplastic, and emphasizes multimodal, individualized care. My overarching goal is to produce personalized approaches for pain in aging and age-related neurodegeneration, built from coherent preclinical-to-clinical signatures, pragmatic trials, and reproducible imaging and biomarker panels.
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